The 22-year-old infielder was acquired by the Rays, along with pitcher Sergio Pedroza, in a July trade last season that sent shortstop Julio Lugo to the Dodgers.
Guzman, who has 70 home runs in 538 Minor League games, hit .188 in 14 games this spring. He will be the third baseman in Durham.
Bill Chastain is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.