"It's a personal thing," Maddon said. "It's something that we were aware of and it just so happens to be today. It is unavoidable."
Maddon said he thought that Ramirez would fly to Chicago on Thursday night.
"The schedule kind of bit him on this personal thing," Maddon said.
Maddon said he did not know if dealing with this problem will be an ongoing thing.
"It's one of those things where I think it might be over," Maddon said. "But you'd have to ask him, if he wants to speak to it. I'm not sure."
Ramirez, who came to the Rays as a free agent, is off to a slow start. After Wednesday's loss to the Angels, Ramirez was hitting .059 (1-for-17) with no home runs and one RBI.