"I know it's early in the season, but I still think he's pressing a bit," Maddon said. "I really think he's trying to carry too much of this load right now. I want him to understand that I'm seeing that, that I think he's trying way too hard. All I want him to do is his part, nobody else's part, that we all can take care of ourselves here.
"I just believe he's trying to shoulder too much of the burden right now, and I don't want him to do that."
Maddon said the tip-offs included watching his designated hitter begin to swing at pitches he "normally wouldn't chase."
Ramirez is 1-for-16 over the season's first four games, though that hit produced one of just six Rays RBIs through Tuesday. He'll also miss Thursday's game, the first of a four-game road trip against the Chicago White Sox, although Maddon said that absence will be due to personal matters.
Ramirez won't fly to Chicago with the Rays after Wednesday's game, but he is slated to rejoin his teammates before Friday's contest.
Maddon was quick to point out that despite the early-season funk, Ramirez is still the same guy who has 555 homers, 1,831 RBIs and 2,574 hits -- 1,122 of those for extra bases.
"With guys like him, I think we forget," Maddon said. "It's not easy to be him sometimes. He's not a potential Hall of Famer -- he will be a Hall of Famer. He's in the latter part of his career, so you're going to have different kind of moments, mentally.
"I've been around players like that in the past, and I think at some point it takes a different understanding from whomever's working with them. From me to him, I just want him to understand that I do know what he's going through, and I want to help him out."